Combining magnetism and light to fight cancer
By combining, in a liposome1, magnetic nanoparticles and photosensitizers that are simultaneously and remotely activated by external physical stimuli (a magnetic field and light), scientists at the Laboratoire Matière et Systèmes Complexes (CNRS/Université Paris Diderot) and the Laboratoire Physicochimie des Electrolytes et Nanosystèmes Interfaciaux (CNRS/UPMC),2 obtained total tumor regression in mice. Non-toxic when they are not activated, such therapies can also achieve a reduction in adverse effects. These results, which demonstrate the importance of multiple treatments, were published in ACS Nano on 24 March 2015.
2In collaboration with scientists from the Paris-Centre de Recherche Cardiovasculaire (Inserm/Université Paris Descartes)
Riccardo Di Corato, Gaëlle Béalle, Jelena Kolosnjaj-Tabi, Ana Espinosa, Olivier Clément, Amanda K. A. Silva, Christine Ménager, et Claire Wilhelm. ACS nano, 24 March 2015. DOI : 10.1021/nn506949t.